Searchable abstracts of presentations at key conferences in endocrinology

ea0094p235 | Neuroendocrinology and Pituitary | SFEBES2023

Short chain fatty acid ameliorates hypothalamic apoptosis in a rat model of polycystic ovarian syndrome via modulation of gamma-aminobutyric acid

Agan Shalom , Areloegbe Stephanie , Bashir Al-Amin , Olaniyi Kehinde

Background of Study: Polycystic ovarian syndrome (PCOS) is an endocrine disorder, contributing to increased neurodegenerative disorders including hypothalamic disturbance. Short chain fatty acid (SCFA) has been reported to regulate metabolic health. However, its therapeutic nature in hypothalamic dysfunction, especially in PCOS individuals is unknown. This study hypothesized that SCFA reverses hypothalamic injury and its related abnormalities in experimentally...